RT Book, Section A1 Portney, Leslie G. SR Print(0) ID 1186213957 T1 Foundations of Statistical Inference T2 Foundations of Clinical Research: Applications to Evidence-Based Practice, 4e YR 2020 FD 2020 PB F. A. Davis Company PP New York, NY SN 9780803661134 LK fadavispt.mhmedical.com/content.aspx?aid=1186213957 RD 2022/05/17 AB The simplest experimental comparison involves the use of two independent groups within a randomized controlled trial (RCT). This design allows the researcher to assume that all individual differences are evenly distributed between the groups at baseline, and therefore, observed differences after the application of an intervention to one group should reflect a significant difference, one that is unlikely to be the result of chance.