RT Book, Section A1 Portney, Leslie G. SR Print(0) ID 1186212401 T1 Design Validity T2 Foundations of Clinical Research: Applications to Evidence-Based Practice, 4e YR 2020 FD 2020 PB F. A. Davis Company PP New York, NY SN 9780803661134 LK fadavispt.mhmedical.com/content.aspx?aid=1186212401 RD 2024/04/18 AB Research designs are intended to provide structure that allows for logical conclusions about the relationship between independent and dependent variables. The investigator must have confidence that extraneous factors have not influenced the outcome. Even with a design that fulfills the requirements of an experiment, such as a randomized controlled trial (RCT), researchers must be vigilant regarding many potential sources of confounding that can obscure the effects of an intervention. Confounders may be extrinsic factors that emerge from the environment and the research situation, or they may be intrinsic factors that represent personal characteristics of the subjects of the study.