RT Book, Section A1 McCulloch, Joseph M. A2 McCulloch, Joseph M. A2 Kloth, Luther C. SR Print(0) ID 1184834444 T1 Compression Therapy T2 Wound Healing Evidence-Based Management, 4e YR 2010 FD 2010 PB McGraw-Hill Education PP New York, NY SN 9780803619043 LK fadavispt.mhmedical.com/content.aspx?aid=1184834444 RD 2023/09/27 AB Fluid accumulates in extravascular tissues in response to changes in various forces normally controlling vessel permeability. Local factors include hydrostatic pressure changes and blockage of lymphatic channels, whereas on a systemic level, protein imbalance can result in generalized swelling. While most swelling is referred to as "edema," the general use of this term can lead to misunderstanding of the underlying pathology and, subsequently, inappropriate treatment. Critical distinctions exist between normal tissue edema and lymphedema, which is due to a dysfunctional lymphatic system. The reader is referred to Chapter 18 for a detailed discussion of this condition.