RT Book, Section A1 Mahoney, Edward A2 McCulloch, Joseph M. A2 Kloth, Luther C. SR Print(0) ID 1184831628 T1 Diabetic Foot Ulcerations T2 Wound Healing Evidence-Based Management, 4e YR 2010 FD 2010 PB McGraw-Hill Education PP New York, NY SN 9780803619043 LK fadavispt.mhmedical.com/content.aspx?aid=1184831628 RD 2024/04/23 AB There are an estimated 23.6 million people in the United States with diabetes, which is roughly 7.8% of the population.1 Although comprising less than 8% of the total population, people with diabetes account for more than 60% of nontraumatic lower limb amputations. In the year 2004, approximately 71,000 nontraumatic lower-limb amputations were performed in people with diabetes.2 The total annual economic cost of diabetes in 2004 was estimated to be $174 billion dollars.1 One of the major complications of diabetes is lower extremity amputation, which is often preceded by ulcer formation. It can be difficult to identify the cause of complications because there are so many factors that play a role in the development of foot problems. As the number of people diagnosed with diabetes and the number of foot complications associated with it continues to rise, it is becoming even more important to develop an understanding of the factors leading to ulceration and, ultimately, strategies to correct them.