RT Book, Section A1 Davidson, Jeffrey M. A2 McCulloch, Joseph M. A2 Kloth, Luther C. SR Print(0) ID 1184829577 T1 Growth Factors and Extracellular Matrix in Wound Repair T2 Wound Healing Evidence-Based Management, 4e YR 2010 FD 2010 PB McGraw-Hill Education PP New York, NY SN 9780803619043 LK fadavispt.mhmedical.com/content.aspx?aid=1184829577 RD 2024/03/28 AB A wound site begins as a void or zone of destruction that must be reorganized by adjacent and circulating cells into a tissue that has both mechanical integrity and proper architecture. This reorganization is determined by the progressive construction and remodeling of an extracellular matrix (ECM) that serves as a scaffold for cell migration and growth. In the absence of a matrix, cells cannot move or carry out their normal duties. The matrix around cells defines a microenvironment that provides both mechanical and biochemical information to cells through specific receptors, and it also acts as a biological buffer for the cell-derived signals that drive wound healing.