RT Book, Section
A1 Dunn, Sharon L.
A2 McCulloch, Joseph M.
A2 Kloth, Luther C.
SR Print(0)
ID 1184829273
T1 The Wound Healing Process
T2 Wound Healing Evidence-Based Management, 4e
YR 2010
FD 2010
PB McGraw-Hill Education
PP New York, NY
SN 9780803619043
LK fadavispt.mhmedical.com/content.aspx?aid=1184829273
RD 2024/04/17
AB Wound  healing  consists  of  a  symphony  of  events  that,  when  well  orchestrated,  results  in  reepithelialization  of  the  skin  and  restoration  of  its  barrier  function.  The  first  event  after  wounding  is  the  establishment  of  hemostasis  by  plugging  the  defect  with  a  fibrin  clot.  This  is  followed  by  overlapping  stages  of  inflammation,  repair  (proliferation),  and  remodeling  (Fig.  2.1).  Cellular  and  humoral  mediators  conduct  the  symphony  and  consist  of  inflammatory  cells  (neutrophils,  lymphocytes,  mast  cells,  and  monocytes/macrophages);  repair  cells  (fibroblasts,  myofibroblasts,  and  fibrocytes);  epithelial  cells  (keratinocytes);  and  soluble  proteins  (cytokines,  chemokines,  enzymes,  and  growth  factors).  The  extracellular  matrix  (ECM)  provides  the  stage  on  which  these  mediators  play,  serving  as  a  physical  scaffold  for  repair  and  presenting  a  milieu  of  protein  intermediates.