RT Book, Section A1 Ciccone, Charles D. SR Print(0) ID 1135035245 T1 Pharmacological Management of Parkinson Disease T2 Pharmacology in Rehabilitation YR 2016 FD 2016 PB F. A. Davis Company PP New York, NY SN 9780803640290 LK fadavispt.mhmedical.com/content.aspx?aid=1135035245 RD 2024/10/07 AB Parkinson disease is a movement disorder characterized by resting tremor, bradykinesia, rigidity, and postural instability.1,2 In Parkinson disease, there is a slow, progressive degeneration of certain dopamine-secreting neurons in the basal ganglia.1,3 Several theories have been proposed to explain this spontaneous neuronal degeneration, including the possibility that the disease may be caused by a combination of genetic and environmental factors (see “Etiology of Parkinson Disease: Genetic and Environmental Factors").4–6 However, the precise initiating factor in Parkinson disease is still unknown.