RT Book, Section A1 Goodman, Catherine A1 Helgeson, Kevin SR Print(0) ID 1133952324 T1 Sickle Cell Trait T2 Exercise Prescription for Medical Conditions: Handbook for Physical Therapists YR 2011 FD 2011 PB McGraw-Hill Education PP New York, NY SN 9780803617148 LK fadavispt.mhmedical.com/content.aspx?aid=1133952324 RD 2024/03/29 AB This is an inherited condition of abnormal hemoglobin production. This condition rarely results in a sickling crisis and is managed differently from sickle cell disease. An exertional sickling crisis usually occurs when athletes or military personnel with this condition overexert themselves, resulting in sickling of red blood cells, which causes clotting and ischemic rhabdomyolysis.1 Most individuals with sickle cell trait do not have painful crises and can participate in regular recreational and competitive activities, but abnormalities of red blood cell parameters may influence their aerobic exercise tolerance.2,3 Dehydration, viral illness, abrupt changes in altitude, and exercising in heat conditions are risk factors for developing exertional sickling.1,4