RT Book, Section A1 Goodman, Catherine A1 Helgeson, Kevin SR Print(0) ID 1133952198 T1 Parkinson's Disease T2 Exercise Prescription for Medical Conditions: Handbook for Physical Therapists YR 2011 FD 2011 PB McGraw-Hill Education PP New York, NY SN 9780803617148 LK fadavispt.mhmedical.com/content.aspx?aid=1133952198 RD 2024/04/25 AB This is a chronic progressive disease involving the subcortical gray matter of the basal ganglia. Most cases are due to a genetic defect, with toxic and infectious exposures being risk factors. The disease progresses as the substantia nigra of the basal ganglia loses its ability to produce dopamine.1 Because the basal ganglia is important for the initiation and control of motor behaviors, the progression of the disease significantly alters how movements occur, resulting in slowing of movement and loss of coordination. A decrease in daily activities and social participation results in deconditioning and a decrease in cardiovascular functions. The Unified Parkinson's Disease Rating Scale and the Hoehn and Yahr Classification of Disability are used to determine disease progression.1