TY - CHAP M1 - Book, Section TI - Sickle Cell Disease A1 - Goodman, Catherine A1 - Helgeson, Kevin PY - 2011 T2 - Exercise Prescription for Medical Conditions: Handbook for Physical Therapists AB - This disease is a group of inherited disorders that produces an abnormal type of hemoglobin that causes red blood cells to take on a sickle shape during deoxygenation. Sickling of red blood cells leads to lysis that results in anemia and vaso-occlusion. Sickled red blood cells form clots in organs, joints, and bones that produce painful episodes or crises. Sickle cell episodes can lead to damage to the spleen, with anemia leading to infections and systemic complications. Clients may have frequent crises that require ongoing medical management and complications. Infants are routinely screened for this disease. Clients are counseled to control their activities and stressors that may trigger a crises episode. Daily activities are difficult to complete if a client with sickle cell disease has chronic anemia.1,2 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - fadavispt.mhmedical.com/content.aspx?aid=1133952304 ER -