TY - CHAP M1 - Book, Section TI - Cancer Chemotherapy A1 - Ciccone, Charles D. A1 - Bednarek, Melissa L. A1 - Miller, Kenneth L. Y1 - 2022 N1 - T2 - Pharmacology in Rehabilitation, 5e AB - Cancer encompasses a group of diseases that are marked by rapid, uncontrolled cell proliferation and a conversion of normal cells to a more primitive and undifferentiated state.1,2 Large tumors, or neoplasms, may form from excessive cell proliferation. Although some types of tumors are well contained (benign), malignant tumors continue to proliferate within local tissues and can possibly spread (metastasize) to other tissues in the body. The term cancer specifically refers to the malignant forms of neoplastic disease, which can often be fatal, as tumors invade and destroy tissues throughout the body. However, benign tumors can also be life-threatening; for example, a large benign tumor may produce morbidity and mortality by obstructing the intestinal tract or by pressing on crucial central nervous system (CNS) structures. Cancer cells, however, are unique in their progressive invasion of local tissues and their ability to metastasize to other tissues.1 SN - PB - F. A. Davis Company CY - New York, NY Y2 - 2024/03/29 UR - fadavispt.mhmedical.com/content.aspx?aid=1188531237 ER -