TY - CHAP M1 - Book, Section TI - Treatment of Coagulation Disorders and Hyperlipidemia A1 - Ciccone, Charles D. A1 - Bednarek, Melissa L. A1 - Miller, Kenneth L. Y1 - 2022 N1 - T2 - Pharmacology in Rehabilitation, 5e AB - Blood coagulation, or hemostasis, is necessary to prevent excessive hemorrhage from damaged blood vessels. Under normal conditions, clotting factors in the bloodstream interact with damaged vessels to create a blood clot that plugs the leaking vessel. Obviously, inadequate blood clotting is harmful in that even minor vessel damage can lead to excessive blood loss. Overactive clotting is also detrimental because it will lead to thrombogenesis (i.e., the abnormal formation of blood clots, or thrombi).1Thrombus formation may lead directly to vessel occlusion and tissue infarction. Also, a piece of a thrombus may dislodge, creating an embolism that causes infarction elsewhere in the body, such as in the lungs or brain. SN - PB - F. A. Davis Company CY - New York, NY Y2 - 2024/03/29 UR - fadavispt.mhmedical.com/content.aspx?aid=1188529786 ER -