TY - CHAP M1 - Book, Section TI - Pharmacological Management of Parkinson Disease A1 - Ciccone, Charles D. A1 - Bednarek, Melissa L. A1 - Miller, Kenneth L. Y1 - 2022 N1 - T2 - Pharmacology in Rehabilitation, 5e AB - Parkinson disease is a movement disorder characterized by resting tremor, bradykinesia, rigidity, and postural instability.1,2 In Parkinson disease, there is a slow, progressive degeneration of certain dopamine-secreting neurons in the basal ganglia.1,3 Several theories have been proposed to explain this spontaneous neuronal degeneration, including the possibility that the disease may be caused by a combination of genetic and environmental factors (see “Etiology of Parkinson Disease: Genetic and Environmental Factors”).4-6 However, the precise initiating factor in Parkinson disease is still unknown. SN - PB - F. A. Davis Company CY - New York, NY Y2 - 2024/03/28 UR - fadavispt.mhmedical.com/content.aspx?aid=1188528463 ER -