TY - CHAP M1 - Book, Section TI - Cirrhosis A1 - Goodman, Catherine A1 - Helgeson, Kevin Y1 - 2011 N1 - T2 - Exercise Prescription for Medical Conditions: Handbook for Physical Therapists AB - This condition is the end-stage disease of the liver resulting from a variety of diseases, most commonly hepatitis C and alcohol abuse. Cirrhosis of the liver tissue is from inflammation, fibrotic scarring, and obstruction of biliary channels. These changes lead to jaundice, portal hypertension, and decreased clearing of waste from the blood. Clients experience more fatigue, malnutrition, and muscle cramping as the disease progresses.1 Fatigue is related to significant reduction in muscle mass and strength and increased presence of ammonia in the circulating plasma.2,3 At end-stage, the client develops ascites of the abdomen and edema in the lower extremities, which may significantly reduce the client's daily activities. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - fadavispt.mhmedical.com/content.aspx?aid=1133951613 ER -