TY - CHAP M1 - Book, Section TI - Principles of Clinical Trials A1 - Portney, Leslie G. PY - 2020 T2 - Foundations of Clinical Research: Applications to Evidence-Based Practice, 4e AB - A clinical trial is a study designed to test hypotheses about comparative effects. Trials are based on experimental designs, within which the investigator systematically introduces changes into natural phenomena and then observes the consequences of those changes. The randomized controlled trial (RCT) is the standard explanatory design, intended to support a cause-and-effect relationship between an intervention (the independent variable) and an observed response or outcome (the dependent variable). SN - PB - F. A. Davis Company CY - New York, NY Y2 - 2024/03/29 UR - fadavispt.mhmedical.com/content.aspx?aid=1186212195 ER -