TY - CHAP M1 - Book, Section TI - Growth Factors and Extracellular Matrix in Wound Repair A1 - Davidson, Jeffrey M. A2 - McCulloch, Joseph M. A2 - Kloth, Luther C. PY - 2010 T2 - Wound Healing Evidence-Based Management, 4e AB - A wound site begins as a void or zone of destruction that must be reorganized by adjacent and circulating cells into a tissue that has both mechanical integrity and proper architecture. This reorganization is determined by the progressive construction and remodeling of an extracellular matrix (ECM) that serves as a scaffold for cell migration and growth. In the absence of a matrix, cells cannot move or carry out their normal duties. The matrix around cells defines a microenvironment that provides both mechanical and biochemical information to cells through specific receptors, and it also acts as a biological buffer for the cell-derived signals that drive wound healing. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - fadavispt.mhmedical.com/content.aspx?aid=1184829577 ER -