TY - CHAP M1 - Book, Section TI - Parkinson's Disease A1 - Goodman, Catherine A1 - Helgeson, Kevin PY - 2011 T2 - Exercise Prescription for Medical Conditions: Handbook for Physical Therapists AB - This is a chronic progressive disease involving the subcortical gray matter of the basal ganglia. Most cases are due to a genetic defect, with toxic and infectious exposures being risk factors. The disease progresses as the substantia nigra of the basal ganglia loses its ability to produce dopamine.1 Because the basal ganglia is important for the initiation and control of motor behaviors, the progression of the disease significantly alters how movements occur, resulting in slowing of movement and loss of coordination. A decrease in daily activities and social participation results in deconditioning and a decrease in cardiovascular functions. The Unified Parkinson's Disease Rating Scale and the Hoehn and Yahr Classification of Disability are used to determine disease progression.1 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/19 UR - fadavispt.mhmedical.com/content.aspx?aid=1133952198 ER -