++
Assessment of these areas should raise concern whether the problem has a systemic or viscerogenic origin.
++
++
Personal/family Hx of cancer
Recent infection when followed by neurological Sx, joint or back pain
Recent Hx of trauma
Hx of immunosuppression
Hx of drug use: injection
++
Risk Factors of Possible Systemic Disease
++
++
++
Insidious onset/unknown etiology
Sx not improved or relieved by physical therapy
Significant weight loss or gain without attempting to lose or gain
Gradual, progressive, or cyclical presentation of Sx
Sx that are unrelieved by rest or change of position
Sx persisting beyond expected time of condition
Sx do not fit typical neuromuscular or musculoskeletal pattern
A growing mass or a hematoma that is not decreasing in size
Postmenopausal bleeding
Bilateral Sx such as edema, numbness, tingling, clubbing, nail bed changes, skin rash, or pigment changes
Change in muscle tone or ROM in those with neurological conditions
++
++
Pain w/full painless ROM
Pain not consistent with psychological overlay
Throbbing or deep, aching pain
Poorly localized pain
Pain that comes and goes like spasms
Pain associated with S&S relating to certain viscera or system, e.g., GI, GU, cardiac, pulmonary
Change of pain with food intake
++
++
Unusual menstrual cycle or Sx
Presence of unusual/abnormal vital signs, including HR, temp, etc
Proximal muscle weakness and/or DTRs
Change in mental status including confusion
Joint pain with skin rashes
+++
Early Warning Cancer Signs (American Cancer Society)
++
Changes in bowel/bladder habits
Sore that does not heal in 6 wk
Unusual bleeding or discharge
Thickening or lump in breast or elsewhere
Indigestion or difficulty in swallowing
Obvious change in wart/mole
Nagging cough or hoarseness
Proximal muscle weakness
Change in deep tendon reflexes
+++
Other Screening Clues
++
Previous personal Hx of any cancer
Recent wt loss of 10 lb or more within 1 mo
Constant pain, unrelieved by rest or change in position
Night pain
Development of new neurological deficits
Changes in size, shape, tenderness, & consistency of lymph nodes, painless & present in >1 location
Women: chest, breast, axillary, or shoulder pain of unknown cause
Bloody sputum
++
Adapted from Goodman C. and Snyder T. Differential Diagnosis for Physical Therapists, ed. 4. Philadelphia: Elsevier, 2006. p. 7.
++
++