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Impairments of the lymphatic system can lead to lymphatic insufficiencies that can result in significant physical impairments and subsequent loss of function of either the upper or lower extremities. Disturbances in structure or function can lead to accumulation of lymphatic fluids in the tissue of the body that affect the physiological health of the tissue, impair joint mobility, and impact daily functioning. Lymphatic dysfunction can be a result of a congenital or hereditary abnormality or can be caused by trauma, infection, or treatment for a cancer.

To contribute to the effective management of patients with lymphatic disorders, a therapist must possess a sound understanding of the underlying pathologies and the clinical manifestations of many types of lymphatic disorders, as well as the interplay between the lymphatic and venous systems. A therapist must also be aware of the use, effectiveness, and limitations of therapeutic exercise in the comprehensive management and rehabilitation of patients with lymphatic insufficiencies.

Disorders of the Lymphatic System

Structure and Function of the Lymphatic System

The primary function of the lymphatic system is to collect and transport fluid from the interstitial spaces back to the venous circulation (Fig. 26.1).36,57,62,69,86,133.135 This is accomplished with a series of lymph vessels and lymph nodes.36,69,135 The lymphatic system also has a role in the body's immune function.36,69,86,133,135 When the lymphatic system is compromised either by impairment of lymphatic structures or by an overload of lymphatic fluid, the result is swelling in the tissue spaces. Edema is a natural consequence of trauma to and subsequent healing of soft tissues. If the lymphatic system is compromised and does not function efficiently, lymphedema develops and impedes wound healing.


Major vessels of the lymphatic system.

Lymphedema is an excessive and persistent accumulation of extravascular and extracellular fluid and proteins in tissue spaces.12,22,32,57,69.74,135 It occurs when lymph volume exceeds the capacity of the lymph transport system, and it is associated with a disturbance of the water and protein balance across the capillary membrane. An increased concentration of proteins draws larger amounts of water into interstitial spaces, leading to lymphedema.32,51,69,135 The accumulation of the extracellular fluid and protein causes a proliferation of adipose tissue in the affected area.14,15,86 Furthermore, many disorders of the cardiopulmonary system can cause the load on lymphatic vessels to exceed their transport capacity and subsequently cause lymphedema.51,74,107

Anatomy of the Lymphatic System

The lymphatic ...

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