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Some of the more frequently abused drugs are listed here. Agents such as cocaine and the psychedelics are illicit drugs with no major pharmacotherapeutic value. Other drugs such as barbiturates, benzodiazepines, and opioids are used routinely for therapeutic reasons but have a strong potential for abuse when taken indiscriminately. Finally, drugs such as alcohol, caffeine, and nicotine are readily available in various commercial products but may also be considered drugs of abuse when consumed in large quantities for prolonged periods.

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