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methodology

(mĕthʺŏ-dŏlʹō-jē) [ʺ + logos, word, reason] The system of principles and procedures used in scientific endeavors.

methotrexate

(mĕthʺō-trĕkʹsāt) An inhibitor of dihydrofolate reductase used to treat rheumatoid arthritis, Crohn’s disease, psoriasis, and several cancers. It also has been used with misoprostol to induce abortion. Side effects from this drug include suppression of bone marrow production of blood cells and hepatitis.

methyl

(methʹĭl) [Gr. methy, wine + -yl] In organic chemistry, the radical CH3–, seen, for instance, in the formula for methyl alcohol, CH3OH.

m. alcohol SEE: methyl alcohol.

m. mercury Methylmercury.

m. orange A dye used as a pH indicator.

m. purine An oxidation product of purine. It includes caffeine, theophylline, and theobromine. SEE: aminopurine; oxypurine.

m. violet A stain used in histology and bacteriology.

methylate

(mĕthʹĭ-lāt) 1. A compound of methyl alcohol and a base. 2. To introduce the methyl group, CH3, into a chemical compound. 3. To mix with methyl alcohol.

methylation

(mĕthʺĭ-lāʹshŭn) The addition of methyl groups to a compound.

methylbenzene

(methʺĭl-benʹzēnʺ) [methyl + benzene] Toluene.

methylcellulose

(mĕthʺĭl-sĕlʹū-lōs) A tasteless powder that becomes swollen and gummy when wet. Methylcellulose is used as a bulk substance in foods and laxatives and as an adhesive or emulsifier.

methylcytosine

(mĕthʺĭl-sīʹtō-sĭn) A derivative of pyrimidine present in some nucleic acids.

methylene

(mĕthʹĭ-lēn) The chemical radical =CH2.

methylene blue

(methʹĭ-lēnʺ) A dark green dye available as a crystalline powder. It produces a distinct blue stain. It is used for treatment of severe methemoglobinemia and, occasionally, anaphylactic or septic shock.

methylglyoxal

(mĕthʺĭl-glī-ŏkʹsĭl, -awl) An aldehyde formed from the metabolic degradation of glucose. Methylglyoxal can bind to proteins and DNA, causing metabolic damage to tissues, e.g., in diabetes mellitus; mutations; or cell death.

methylhydroxychalcone polymer

(methʺĭl-hī-drokʺsē-kalʹkōnʺ) [methyl + hydroxy + chalcone, an aromatic ketone] ABBR: MHCP. An ingredient in cinnamon that in vitro improves insulin sensitivity.

methylmalonic acidemia

(methʺĭl-mă-lonʹik) SEE: under acidemia.

methylmercury, methyl mercury

(mĕ-thĭl-mĕrʹkū-rē) An organic mercury compound produced from inorganic mercury by the addition of a methyl group (CH3) by marine and soil bacteria. This compound is readily taken up by plankton, which are then consumed ...

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