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(lob′yŭ-lŭs, lob′yŭ-lĭ″) pl. lobuli [L., diminutive of lobus] A lobule or small division of a lobe.


(lō′bŭs, lō′bī″) pl. lobi [L. lobus, fr. Gr. lobos, hull, pod, lobe] A lobe. SEE: lobe.


1. levels of consciousness. 2. loss of consciousness.


(lō′kăl) [L. locus, place] Limited to one place or part.

local effect of a drug

The impact of a therapeutic agent on specific tissues rather than on the whole body, esp. on those tissues where the agent is absorbed, metabolized, or most chemically active.


(lō″kă-lĭ-zā′shŏn) [local] 1. Limitation to a definite area. 2. Determination of the site of an infection. 3. Relation of a sensation to its point of origin. 4. Identification of a lesion in three-dimensional space, e.g., radiographically, or by reference to anatomical landmarks, hemoclips, needles, wires or skin tattoos.

cerebral l. Determination of centers of various faculties and functions in particular parts of the brain.

needle l. The insertion of a thin, radiographically guided metal wire into a small suspicious lesion to direct the surgeon to the lesion, making it easier for biopsy or removal. SYN: wire localization.

tactile l. An individual’s ability to accurately identify the site of tactile stimulation (touch, pressure, or pain). Tactile localization is often tested in sensory evaluations following disease or trauma of the central nervous system.

wire l. Needle l.


(lō′kăl-īzd) Restricted to a limited region.


(lō′kăl-ĭ″zĕr) An apparatus used for finding foreign bodies or exact anatomical locations during radiography.

locally advanced

Large or bulky; said of a malignant tumor that has grown substantially at its site of origin.

local reaction

A reaction occurring at the point of stimulation or injection of foreign substances.

local recurrence

The reappearance of a cancer after treatment at the site at which it was originally detected.


(lō′kā-tĕr) A device for locating or discovering an object such as a foreign body.


(lō′kă-vor″) [loca(l) + L. vorare, to devour] One who eats foods grown and/or produced within approximately a 100-mile radius of his or her home.


(lō′kē-ă) [Gr. lochia, childbirth] The puerperal discharge of blood, mucus, and tissue from the uterus. The character of the discharge progresses through three stages in the normal ...

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