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osteon, osteone

(os′tē-on″, os′tē-ōn″) [Gr. osteon, bone] The microscopic unit of compact bone, consisting of a haversian canal and the surrounding lamellae. SEE: haversian system.


(os″tē-ō-nĕ-krō′sĭs) [osteo- + necrosis] The death of a segment of bone, usually caused by insufficient blood flow to a region of the skeleton.

INCIDENCE: It is a relatively common disorder, accounting for 10% of all joint replacements.

CAUSES: Between 5 and 25% of patients receiving prolonged therapy with corticosteroids develop osteonecrosis. The disease also occurs in sickle cell anemia, as a result of bone infarcts; in the jaw of some cancer patients treated with bisphosphonates; and after repetitive joint trauma, as in contact sports like football.

TREATMENT: Prosthetic joint replacement is sometimes required. SYN: avascular necrosis.


(ŏs″tē-ō-nĕk′tĭn) A glycoprotein present in the noncollagenous portion of the matrix of bone.


(ŏs′tē-ō-păth) [″ + pathos, disease] A practitioner of osteopathy.


(os″tē-ō-path ē-ă) [osteo- + -pathy] 1. Any disease that affects bone. 2. Osteopathy.


(ŏs″tē-ō-păth-ŏl′ō-jē) [″ + pathos, disease, + logos, word, reason] 1. Any bone disease. SYN: osteopathy (1). 2. The study of bone diseases.


(os-tē-op′ă-thē) [osteo- + -pathy] 1. Any bone disease. 2. A system of medicine historically based on the theory that disease is caused by impaired functional integrity and is restored by manipulation. Contemporary osteopaths rely much more heavily on the use of medications and surgery than upon body adjustments. Osteopathy is recognized as a standard method or system of medical and surgical care. Physicians with a degree in osteopathy use the designation DO. SYN: osteopathic medicine. osteopathic (os tē-ō-path ik), adj.

diabetic o. Charcot foot.


(os″tē-ō-pē′nē-ă) [osteo- + -penia] A significant decrease in the amount of bone mineral density (BMD) normally found in a population or group. The World Health Organization specifies that when BMD is between 1 and 2.5 standard deviations below normal, osteopenia exists. Decreases in BMD that exceed 2.5 standard deviations below normal are called osteoporosis. SEE: osteoporosis.

INCIDENCE: Reductions in bony mineralization are found in approx. 40% of women over the age of 50. The incidence and prevalence are higher among Asian American and European American women than in African American women.


(os″tē-ō-per″ē-os′tē-ăl) [osteo- + periosteal] Pert. to bone and its periosteum.


(ŏs″tē-ō-pĕ-trō′sĭs) [″ + petra, stone, + osis, condition] A rare ...

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