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leukocyte trafficking

The immigration of white blood cells into tissues, e.g. into the walls of the intestines in chronic inflammatory diseases such as ulcerative colitis.


(loo″kō-sĭt′ĭk) [″ + kytos, cell] Pert. to leukocytes.


(loo″kō-sī′tō-blast) [″ + ″ + blastos, germ] A cell from which a leukocyte arises.


(loo″kō-sī-tōl′ĭ-sĭn) A lysin that destroys leukocytes. SEE: leukocidin.


(loo″kō-sī-tŏl′ĭ-sĭs) [″ + kytos, cell, + lysis, dissolution] Destruction of leukocytes.


(loo″kō-sī″tō-pē′nē-ă) [″ + ″ + penia, want] Leukopenia.


(loo″kō-sī″tō-poy-ē′sĭs) [″ + ″ + poiein, to make] The formation of white blood cells.


(loo″kō-sī-tō′sĭs) [″ + kytos, cell, + osis, condition] An increase in the number of leukocytes (usually above 10,000/mm3) in the blood. It occurs most commonly in disease processes involving infection, inflammation, trauma, or stress, but it also can result occasionally from the use of some medications, e.g., corticosteroids. SEE: leukocyte; leukopenia.

It usually is caused by an increase in one particular type of white blood cell (WBC). For example, neutrophils increase in acute bacterial infections and inflammation, monocytes increase in chronic infections, lymphocytes increase in viral and chronic bacterial infections, and eosinophils increase in allergic disorders, such as asthma. Leukemias often cause a huge increase in circulating cells, owing to the unchecked reproduction of a single clone of malignant cells.

basophilic l. An increase in the basophils in the blood.

mononuclear l. An increase in the monocytes in the blood.

pathological l. Leukocytosis due to a disease such as an infection.


(loo″kŏ-sīt″spĕr-mē-ă) [leukocyte + sperm + -ia] The presence of more than 100,000 white blood cells per mL of semen. It is associated with male infertility.


(loo″kō-sī″tō-tăk′sĭs) [Gr. leukos, white, + kytos, cell, + taxis, arrangement] The movement of leukocytes either toward or away from an area such as a traumatized or infected site.


(loo″kō-sī″tō-tŏk′sĭn) [″ + ″ + toxikon, poison] A toxin that destroys leukocytes. SYN: leukotoxin.


(loo″kŏ-dĕr′mă) [leuko- + derma] Deficiency of skin pigmentation, esp. in patches. SEE: vitiligo.

l. acquisitum centrifugum Halo nevus.


(loo″kō-dĭs′trō-fē) Any disease (such as globoid cell leukodystrophy, adrenoleukodystrophy, or metachromatic leukodystrophy) whose hallmarks are metabolic defects in the formation of myelin. Bone marrow transplantation can cure some affected children.


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