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INTRODUCTION

sinecatechins (sin-e-kat-e-kins)

Veregen

Classification

Therapeutic: antivirals

Pharmacologic: botanical agents

Indications

Treatment of external genital and perianal warts (Condylomata acuminata caused by human papillomavirus [HPV]) in immunocompetent patients 18 yr and older.

Action

Beneficial effects may be due to antioxidant properties; made from extract of green tea. Therapeutic Effects: Regression of warts

Adverse Reactions/Side Effects

Local: burning, edema, erythema, induration, pain/discomfort, pruritus, erosion/ulceration, vesicular rash, bleeding, desquamation, discharge, irritation, phimosis, rash, regional lymphadenitis, scar.

PHYSICAL THERAPY IMPLICATIONS

Examination and Evaluation

  • Monitor any new or increased skin reactions at the site of application, including pain, inflammation, irritation, bleeding, burning, swelling, exfoliation, and rash. Report severe or prolonged skin reactions to the physician.

Patient/Client-Related Instruction

  • Check that the patient and family or caregivers understand topical application procedures and adhere to the recommended dosing schedule.

Pharmacokinetics

Absorption: Minimal systemic absorption (less than that of a cup of green tea).

Distribution: Unknown.

Metabolism and Excretion: Unknown.

Half-life: Unknown.

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TIME/ACTION PROFILE

ROUTE ONSET PEAK DURATION
topical unknown unknown unknown

Contraindications/Precautions

Contraindicated in: Not to be used for urethral, intra-vaginal, cervical, rectal, or intra-anal human papilloma viral disease or on open wounds.

Use Cautiously in: Safe and effective use in immunosuppressed patients has not been established; OB: Use during pregnancy only if potential maternal benefit justifies potential risk to the fetus; Pedi: Safe and effective use in patients <18 yr has not been established.

Interactions

Drug-Drug: None noted.

Route/Dosage

PO (Adults>18 yr): apply to warts tid for up to 16 wk.

Availability

15% Ointment: 15-g tubes.

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