Therapeutic: antivirals (topical)
Pharmacologic: nucleoside analogues
Recurrent herpes labialis (cold sores).
Inhibits viral DNA synthesis and replication. Therapeutic Effects: Death of herpes virus. Decreases lesion duration and pain. Active against herpes viruses.
Adverse Reactions/Side Effects
CNS: headache. Local: application site reactions.
PHYSICAL THERAPY IMPLICATIONS
Examination and Evaluation
Avoid contact with cutaneous or mucosal lesions when treating patient.
Always wash hands thoroughly and disinfect equipment (whirlpools, electrotherapeutic devices, treatment tables, and so forth) to help prevent the spread of infection. Employ universal precautions as indicated for specific patients.
Advise patient to apply medication as directed. Penciclovir should not be used more frequently or longer than prescribed.
Remind patient that penciclovir does not cure herpes infections. The virus lies dormant in nerve cells, and this drug will not prevent the spread of infection to others.
Instruct patient and family/caregivers to report other troublesome side effects, including severe or prolonged headache.
Absorption: Not absorbed following topical use.
Metabolism and Excretion: Converted intracellularly to active triphosphate form; excreted in urine.
Contraindicated in: Hypersensitivity to penciclovir or other components of the formulation.
Use Cautiously in: Pregnancy, lactation, or children (safety not established).
Drug-Drug: None significant.
PO (Adults): Apply 1% cream q 2 hr for 4 days while awake.