Granulocyte colony-stimulating factor (G-CSF)
Therapeutic: colony-stimulating factors
Pharmacologic: hematopoietic growth factors
Prevention of febrile neutropenia and associated infection in patients who have received bone marrow–depressing antineoplastics for the treatment of nonmyeloid malignancies. Reduction of time for neutrophil recovery and duration of fever in patients undergoing induction and consolidation chemotherapy for acute myelogenous leukemia. Reduction of time to neutrophil recovery and sequelae of neutropenia in patients with nonmyeloid malignancies undergoing myeloablative chemotherapy followed by bone marrow transplantation. Mobilization of hematopoietic progenitor cells into peripheral blood for collection by leukapheresis. Management of severe chronic neutropenia. Unlabeled Use: Neutropenia associated with HIV infection.
A glycoprotein, filgrastim binds to and stimulates immature neutrophils to divide and differentiate. Also activates mature neutrophils. Therapeutic Effects: Decreased incidence of infection in patients who are neutropenic from chemotherapy or other causes. Improved harvest of progenitor cells for bone marrow transplantation.
Adverse Reactions/Side Effects
Hemat: excessive leukocytosis. Local: pain, redness at SC site. MS: medullary bone pain.
PHYSICAL THERAPY IMPLICATIONS
Examination and Evaluation
Be alert for signs of increased white blood cell counts (leukocytosis), including fever, weakness, weight loss, loss of appetite, dizziness, fainting, dyspnea, bleeding/bruising, or pain or tingling in the arms, legs, or abdomen. Report these signs to the physician or nursing staff immediately.
Assess any bone pain to rule out musculoskeletal pathology; that is, try to determine if pain is drug induced rather than caused by fracture or biomechanical problems.
Monitor subcutaneous injection site for pain, swelling, and inflammation. Report prolonged or excessive injection-site reactions to the physician.
Absorption: Well absorbed after SC administration.
Metabolism and Excretion: Unknown.
Contraindicated in: Hypersensitivity to filgrastim or Escherichia coli–derived proteins.
Use Cautiously in: Malignancy with myeloid characteristics; Preexisting cardiac disease; Pregnancy, lactation, or children (safety not established).
Drug-Drug: Simultaneous use with antineoplastics may have adverse effects on rapidly proliferating neutrophils—avoid ...