Skip to Main Content

We have a new app!

Take the Access library with you wherever you go—easy access to books, videos, images, podcasts, personalized features, and more.

Download the Access App here: iOS and Android. Learn more here!


eltrombopag (el-trom-boe-pag)



Therapeutic: antithrombocytopenics

Pharmacologic: thrombopoietin receptor agonists


Treatment of chronic immune (idiopathic) thrombocytopenic purpura in patients who have had an inadequate response to corticosteroids, immunoglobulins, or splenectomy.


Increases platelet production by initiating proliferation and differentiation of megakaryocytes from bone marrow progenitor cells. Therapeutic Effects: Increased platelet count with reduced risk of bleeding.

Adverse Reactions/Side Effects

EENT: development/worsening of cataracts. GI: HEPATOTOXICITY. Hemat: bone marrow changes.


Examination and Evaluation

  • Be alert for signs of hepatotoxicity, including anorexia, abdominal pain, severe nausea and vomiting, yellow skin or eyes, fever, sore throat, malaise, weakness, facial edema, lethargy, and unusual bleeding or bruising. Report these signs to the physician immediately.

  • Assess skin periodically for red and purple patches (purpura). If successful, drug therapy should result in a decrease in the frequency and severity of these reactions.

  • Monitor signs of anemia (unusual fatigue, shortness of breath with exertion, bruising) that might indicate bone marrow changes. Notify physician if these signs occur.

Patient/Client-Related Instruction

  • Instruct patient to report any vision disturbances or cloudy, blurred vision.


Absorption: 52% absorbed following oral administration.

Distribution: Unknown.

Protein Binding: >99%.

Metabolism and Excretion: Extensively metabolized; 59% eliminated in feces, 20% as unchanged drug; 31% excreted in urine as metabolites.

Half-life: 21–35 hr.

|Download (.pdf)|Print

TIME/ACTION PROFILE (effect on platelet count)

PO 1 wk 2 wk 1 wk


Contraindicated in: Lactation: Lactation.

Use Cautiously in: Myelodysplastic syndromes (may ↑ risk of hematologic malignancy); Hepatic impairment (lower initial dose may be required); Patients with East Asian ancestry (may require lower doses); Geri: Elderly patients may be more sensitive to drug effects; increase dose cautiously, consider age-related decrease in renal and hepatic function, concurrent disease states, and drug therapy; OB: Use in pregnancy only when potential maternal benefit outweighs potential risk to fetus.


Drug-Drug: ↓ availability and absorption of iron, calcium, aluminum, magnesium, selenium, and zinc by chelation; do not administer within 4 hr of medications containing these and other polyvalent cations.

Drug-Food: ↓ availability and absorption of iron, calcium, aluminum, magnesium, selenium, and zinc by chelation; do not administer within 4 hr of foods containing these and other polyvalent cations.


PO (Adults): 50 mg once daily, may be increased to achieve a platelet count of ≥50 × 10...

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.