Clobetasol

INTRODUCTION

Interventions

• Protect skin from breakdown, especially over bony prominences.

Patient/client-Related Instruction

• Advise patients on long-term treatment to consult physician before stopping this medication. Stopping the medication suddenly may result in adrenocortical shock (severe hypotension, hypoglycemia, weakness, vomiting). If these signs appear, notify physician immediately; may be life threatening.

• Check that the patient and family or caregivers understand topical application procedures and adhere to the recommended dosing schedule.

Pharmacokinetics

Absorption: Minimal. Prolonged use on large surface areas or large amounts applied or use of occlusive dressings may increase systemic absorption.

Distribution: Remains primarily at site of action.

Metabolism and Excretion: Usually metabolized in skin; may be modified to resist local metabolism and have a prolonged local effect.

Half-life: Unknown.

Contraindications/Precautions

Contraindicated in: Hypersensitivity or known intolerance to corticosteroid or components of vehicles (ointment or cream base, preservative, alcohol); Untreated bacterial or viral infections.

Use Cautiously in: Hepatic dysfunction; Diabetes mellitus, cataracts, glaucoma, or tuberculosis (use of large amounts of high-potency agents may worsen condition); Patients with preexisting skin atrophy; OB/Lactation/Pedi: Pregnancy, lactation, or children (chronic high-dose use may result in adrenal suppression in mother, growth suppression in children; children may be more susceptible to adrenal and growth suppression); Not recommended for use in children <12 yr.

Interactions

Drug-Drug: None significant.

Route/Dosage

Topical (Adults and Children): Apply to affected area(s) 1–3 times daily (depends on preparation and condition being treated).

Availability (generic available)

Cream: 0.05%. Emollient cream: 0.05%. Foam: 005%. Gel: 0.05%. Lotion: 0.05%. Ointment: 0.05%. Scalp solution: 0.05%. Shampoo: 0.05%. Spray: 0.05%.