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ceftriaxone (sef-try-aks-one)



Therapeutic: anti-infectives

Pharmacologic: third-generation cephalosporins


Treatment of Skin and skin structure infections, Bone and joint infections, Complicated and uncomplicated urinary tract infections, Uncomplicated gynecologic infections, including gonorrhea, Lower respiratory tract infections, intra-abdominal infections, septicemia, Meningitis, otitis media. Perioperative prophylaxis.


Binds to the bacterial cell wall membrane, causing cell death. Therapeutic Effects: Bactericidal action against susceptible bacteria. Spectrum: similar to that of second-generation cephalosporins, but activity against staphylococci is less, while activity against gram-negative pathogens is greater, even for organisms resistant to first- and second-generation agents. Notable is increased action against: Acinetobacter, Enterobacter, Haemophilus influenzae (including β-lactamase—producing strains), Haemophilus parainfluenzae, Escherichia coli, Klebsiella pneumoniae, Morganella morganii, Neisseria, Proteus, Providencia, Serratia, Moraxella catarrhalis. Has some activity against anaerobes, including Bacteroides fragilis. Not active against methicillin-resistant staphylococci or enterococci.

Adverse Reactions/Side Effects

CNS: SEIZURES (HIGH DOSES). GI: PSEUDOMEMBRANOUS COLITIS, diarrhea, cholelithiasis, sludging in the gallbladder. Derm: rashes, urticaria. Hemat: bleeding, eosinophilia, hemolytic anemia, leukopenia, thrombocytosis. Local: pain at IM site, phlebitis at IV site. Misc: ALLERGIC REACTIONS, INCLUDING ANAPHYLAXIS, superinfection.


Examination and Evaluation

  • Watch for seizures; notify physician immediately if patient develops or increases seizure activity.

  • Monitor signs of pseudomembranous colitis, including diarrhea, abdominal pain, fever, pus or mucus in stools, and other severe or prolonged GI problems (nausea, vomiting, heartburn). Notify physician or nursing staff immediately of these signs.

  • Monitor signs of allergic reactions and anaphylaxis, including pulmonary symptoms (tightness in the throat and chest, wheezing, cough dyspnea) or skin reactions (rash, pruritus, urticaria). Notify physician or nursing staff immediately if these reactions occur.

  • Monitor signs of blood dyscrasias, including eosinophilia (fatigue, weakness, myalgia), hemolytic anemia (malaise, dizziness, jaundice, abdominal pain), leukopenia (fever, sore throat, mucosal lesions, signs of infection), thrombocytopenia (bruising, nose bleeds, bleeding gums, other unusual bleeding), or thrombocytosis (headache, dizziness, chest pain, fainting, visual disturbances, numbness or tingling in the hands and feet). Report these signs to the physician.

  • Monitor injection site for pain, swelling, and irritation. Report prolonged or excessive injection site reactions to the physician.


  • Always wash hands thoroughly and disinfect equipment (whirlpools, electrotherapeutic devices, treatment tables, and so forth) to help prevent the spread of infection. Use universal precautions or isolation procedures as indicated for specific patients.

Patient/Client-Related Instruction

  • Instruct patient to notify physician immediately of signs of superinfection, including black, furry overgrowth on tongue, vaginal itching or discharge, and loose or foul-smelling stools.

  • Instruct patient and family/caregivers to report other troublesome side effects such as severe or prolonged fever, skin problems (rash, hives), diarrhea, or signs of gallstones (sudden intense pain in the abdomen or ...

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