alclometasone (topical) (al-kloe-met-a-sone)
Therapeutic: anti-inflammatories (steroidal)
Management of inflammation and pruritus associated with various allergic/immunologic skin problems.
Suppresses normal immune response and inflammation. Therapeutic Effects: Suppression of dermatologic inflammation and immune processes. Adverse Reactions/Side Effects Derm: allergic contact dermatitis, atrophy, burning, dryness, edema, folliculitis, hypersensitivity reactions, hypertrichosis, hypopigmentation, irritation, maceration, miliaria, perioral dermatitis, secondary infection, striae. Misc: adrenal suppression (use of occlusive dressings, long-term therapy).
PHYSICAL THERAPY IMPLICATIONS
Examination and Evaluation
Assess the area being treated to help document whether drug therapy is successful in resolving skin conditions.
Monitor any new or increased reactions at the site of application, including inflammation, irritation, infection, burning, swelling, exfoliation, and rash. Report severe or prolonged skin reactions to the physician.
Report signs of adrenal suppression, including hypotension, weight loss, weakness, nausea, vomiting, anorexia, lethargy, confusion, and restlessness.
Advise patients on long-term treatment to consult physician before stopping this medication. Stopping the medication suddenly may result in adrenocortical shock (severe hypotension, hypoglycemia, weakness, vomiting). If these signs appear, notify physician immediately; may be life threatening.
Check that the patient and family or caregivers understand topical application procedures, and adhere to the recommended dosing schedule.
Absorption: Minimal. Prolonged use on large surface areas or large amounts applied or use of occlusive dressings may increase systemic absorption.
Distribution: Remains primarily at site of action.
Metabolism and Excretion: Usually metabolized in skin.
TIME/ACTION PROFILE (response depends on condition being treated)
|ROUTE ||ONSET ||PEAK ||DURATION |
|topical ||min–hrs ||hrs–days ||hrs–days |
Contraindicated in: Hypersensitivity or known intolerance to corticosteroids or components of vehicle (ointment base or preservatives); Untreated bacterial or viral infections.
Use Cautiously in: Hepatic dysfunction; Diabetes mellitus, cataracts, glaucoma, or tuberculosis (if significant systemic absorption occurs, condition may worsen); Patients with preexisting skin atrophy; OB/Lactation: Chronic use at high-dosages may result in adrenal suppression in mother and growth suppression in children; Pedi: Children may be more susceptible to adrenal and growth suppression).
Drug-Drug: None significant.
Topical (Adults): Apply to affected area(s) 2–3 times daily (depends on condition being treated).
Cream: 0.05% Rx. Ointment: 0.05% Rx.