RT Book, Section A1 Goodman, Catherine A1 Helgeson, Kevin SR Print(0) ID 1133952063 T1 Multiple Sclerosis (MS) T2 Exercise Prescription for Medical Conditions: Handbook for Physical Therapists YR 2011 FD 2011 PB McGraw-Hill Education PP New York, NY SN 9780803617148 LK fadavispt.mhmedical.com/content.aspx?aid=1133952063 RD 2024/04/20 AB MS is characterized by the development of sclerotic plaques in the central nervous system, which results in blocked or slowed neural transmissions. MS has episodes of increased symptoms followed by periods of recovery. There are four subtypes, based on the pattern of progression of the disease. Initial symptoms are sensory changes, visual deficits, muscle weakness, and balance impairments. Diagnosis of MS is based on the clinical presentation of symptoms and the identification of lesions on magnetic resonance imaging (MRI) of the central nervous system. Clients with MS have periods of increased fatigue and weakness, resulting in limited daily activities. Inactivity is linked to decreased aerobic capacity, reduced muscle strength, increased fatigue, and reduced maximum gait velocity.1