RT Book, Section A1 Goodman, Catherine A1 Helgeson, Kevin SR Print(0) ID 1133951679 T1 Cushing Syndrome T2 Exercise Prescription for Medical Conditions: Handbook for Physical Therapists YR 2011 FD 2011 PB McGraw-Hill Education PP New York, NY SN 9780803617148 LK fadavispt.mhmedical.com/content.aspx?aid=1133951679 RD 2024/04/19 AB This condition results from excessive levels of cortisol, usually due to adrenocortical tumors or high doses of hydrocortisone or cortisol-derivative drugs. Excessive cortisol results in numerous physiological responses, which include muscle weakness, bone demineralization, weakening of elastic tissues, hyperglycemia, and obesity. Removal of adrenocortical tumors will reverse this syndrome, but patients who rely on hydrocortisone to control their inflammatory disease processes may be unable to reverse this syndrome completely. Removal of the tumor may affect other pituitary hormones, especially growth hormone.1 The loss of muscle tissues will greatly affect tolerance for daily activities and lead to deconditioning with impaired endurance.