TY  - CHAP
M1  - Book, Section
TI  - Genetics
A1  - Roy, Serge H.
A1  - Wolf, Steven L.
A1  - Scalzitti, David A.
PY  - 2013
T2  - The Rehabilitation Specialist's Handbook, 4e
AB  - Table  Graphic  Jump  LocationTABLE  13.1Example  Genes  Associated  With  Exercise  PerformanceView  Table||Download  (.pdf)TABLE  13.1Example  Genes  Associated  With  Exercise  PerformanceGene  SymbolFull  Name  Biological  Function(s)Factor  of  InterestOMIM  NumberGene  Map  LocusClinical  RelevanceFor  More  InformationACEAngiotensin  I–Converting  EnzymeACE  plays  an  important  role  in  the  conversion  of  angiotensin  I  into  angiotensin  II,  a  potent  vasopressor.Muscle  mechanical  efficiency10618017q23Response  to  aerobic  exercise  training  is  dependent  on  ACE  genotype.Williams,  AG,  and  Rayson,  MP:  Nature  403:614–615,  2000.ACTN3Al  pha-Actinin-3ACTN3  regulates  the  expression  of  the  actin-binding  protein  alpha-actinin  and  is  expressed  in  type  2  (fast)  skeletal  muscle  fibers.Muscle  force  generating  capacity10257411q13-q14The  ACTN3  577R  allele  provides  an  advantage  for  power  and  sprint  activities.ACTN3  R577X  genotype  influences  the  response  to  strength  training  in  older  adults.Yang,  N,  et  al:  Am  J  Hum  Genetics  73:627–631,  2003.Delmonico,  MJ,  et  al:  J  Gerontol  62A(2):  206–212,  2007.APOEApolipoprotein  EAPOE  is  involved  in  lipid  transport  and  metabolism.  There  are  three  alleles  (variants)  of  this  gene  (APOE2,  APOE3,  and  APOE4).High-density  lipoprotein  cholesterol  (HDL-C)10774119q13.2Ethnicity  interacts  with  E2/3  genotype  at  the  APOE  gene  locus  to  influence  response  to  endurance  training.Physical  activity  participation  may  counteract  the  potentially  deleterious  effects  of  the  APOE4  genotype  on  lipid  profiles.Obisesan,  TO.  et  al:  Metabolism  57:  1669–1676,  2008.Bernstein,  MS,  et  al:  Arterioscler  Thromb  Vasc  Bio  22(1):  133–140,  2002.Based  on:  National  Center  for  Biotechnology  Information,  National  Library  of  Medicine  (Bethesda,  MD):  Entrez  Gene.  http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene.  Accessed  May  29,  2009.  McKusick-Nathans  Institute  of  Genetic  Medicine,  Johns  Hopkins  University  (Baltimore,  MD),  and  National  Center  for  Biotechnology  Information,  National  Library  of  Medicine  (Bethesda,  MD):  Online  Mendelian  Inheritance  in  Man,  OMIM  (TM)  http://www.ncbi.nlm.nih.gov/omim/.  Accessed  May  21,  2009.  OMIM  is  a  compendium  of  human  genes  and  genetic  phenotypes.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - fadavispt.mhmedical.com/content.aspx?aid=1133420887
ER  -