TY - CHAP M1 - Book, Section TI - Compression Therapy A1 - McCulloch, Joseph M. A2 - McCulloch, Joseph M. A2 - Kloth, Luther C. Y1 - 2010 N1 - T2 - Wound Healing Evidence-Based Management, 4e AB - Fluid accumulates in extravascular tissues in response to changes in various forces normally controlling vessel permeability. Local factors include hydrostatic pressure changes and blockage of lymphatic channels, whereas on a systemic level, protein imbalance can result in generalized swelling. While most swelling is referred to as "edema," the general use of this term can lead to misunderstanding of the underlying pathology and, subsequently, inappropriate treatment. Critical distinctions exist between normal tissue edema and lymphedema, which is due to a dysfunctional lymphatic system. The reader is referred to Chapter 18 for a detailed discussion of this condition. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/24 UR - fadavispt.mhmedical.com/content.aspx?aid=1184834444 ER -