|ACE || |
Angiotensin I–Converting Enzyme
ACE plays an important role in the conversion of angiotensin I into angiotensin II, a potent vasopressor.
|Muscle mechanical efficiency ||106180 ||17q23 ||Response to aerobic exercise training is dependent on ACE genotype. ||Williams, AG, and Rayson, MP: Nature 403:614–615, 2000. |
|ACTN3 || |
ACTN3 regulates the expression of the actin-binding protein alpha-actinin and is expressed in type 2 (fast) skeletal muscle fibers.
|Muscle force generating capacity ||102574 ||11q13-q14 || |
The ACTN3 577R allele provides an advantage for power and sprint activities.
ACTN3 R577X genotype influences the response to strength training in older adults.
Yang, N, et al: Am J Hum Genetics 73:627–631, 2003.
Delmonico, MJ, et al: J Gerontol 62A(2): 206–212, 2007.
|APOE || |
APOE is involved in lipid transport and metabolism. There are three alleles (variants) of this gene (APOE2, APOE3, and APOE4).
|High-density lipoprotein cholesterol (HDL-C) ||107741 ||19q13.2 || |
Ethnicity interacts with E2/3 genotype at the APOE gene locus to influence response to endurance training.
Physical activity participation may counteract the potentially deleterious effects of the APOE4 genotype on lipid profiles.
Obisesan, TO. et al: Metabolism 57: 1669–1676, 2008.
Bernstein, MS, et al: Arterioscler Thromb Vasc Bio 22(1): 133–140, 2002.