Example Genes Associated With Exercise Performance
TABLE 13.1Example Genes Associated With Exercise Performance |Favorite Table|Download (.pdf) TABLE 13.1 Example Genes Associated With Exercise Performance
|Gene Symbol ||Full Name Biological Function(s) ||Factor of Interest ||OMIM Number ||Gene Map Locus ||Clinical Relevance ||For More Information |
|ACE || |
Angiotensin I–Converting Enzyme
ACE plays an important role in the conversion of angiotensin I into angiotensin II, a potent vasopressor.
|Muscle mechanical efficiency ||106180 ||17q23 ||Response to aerobic exercise training is dependent on ACE genotype. ||Williams, AG, and Rayson, MP: Nature 403:614–615, 2000. |
|ACTN3 || |
ACTN3 regulates the expression of the actin-binding protein alpha-actinin and is expressed in type 2 (fast) skeletal muscle fibers.
|Muscle force generating capacity ||102574 ||11q13-q14 || |
The ACTN3 577R allele provides an advantage for power and sprint activities.
ACTN3 R577X genotype influences the response to strength training in older adults.
Yang, N, et al: Am J Hum Genetics 73:627–631, 2003.
Delmonico, MJ, et al: J Gerontol 62A(2): 206–212, 2007.
|APOE || |
APOE is involved in lipid transport and metabolism. There are three alleles (variants) of this gene (APOE2, APOE3, and APOE4).
|High-density lipoprotein cholesterol (HDL-C) ||107741 ||19q13.2 || |
Ethnicity interacts with E2/3 genotype at the APOE gene locus to influence response to endurance training.
Physical activity participation may counteract the potentially deleterious effects of the APOE4 genotype on lipid profiles.
Obisesan, TO. et al: Metabolism 57: 1669–1676, 2008.
Bernstein, MS, et al: Arterioscler Thromb Vasc Bio 22(1): 133–140, 2002.
Example Genes Associated With Musculoskeletal Conditions
TABLE 13.2Example Genes Associated With Musculoskeletal Conditions |Favorite Table|Download (.pdf) TABLE 13.2 Example Genes Associated With Musculoskeletal Conditions
|Gene Symbol ||Full Name Biological Function(s) ||Disease ||OMIM Number ||Gene Map Locus ||Clinical Relevance ||For More Information |
|COL9A2 || |
Collagen, Type IX, Alpha-2; Trp 2 Allele
COL9A2 encodes one of the three alpha chains of type IX collagen, the major component of hyaline cartilage.
|Intervertebral disc degeneration ||120260 ||1p33-p32.2 ||The Trp2 allele of COL9A2 is a risk factor for the development and severity of intervertebral disc degeneration. ||Jim, JJT, et al: Spine 30(24):2735–2742, 2005. |
|IL1B || |
This member of the interleukin 1 cytokine family is an important mediator of the acute inflammatory response.
|Rotator cuff lesions with shoulder stiffness ||147720 ||20q14 ||Shoulder stiffness is associated with increased IL1B expression and with greater myofibroblast recruitment into the subacromial bursa in rotator cuff lesions. ||Ko JY, ...|
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