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INTRODUCTION

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somatropin (recombinant) (soe-ma-troe-pin)

Zorbtive

Classification

Therapeutic: hormones

Pharmacologic: growth hormones

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Indications
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Treatment of short bowel syndrome in patients receiving specialized nutritional support.

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Action
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Produce growth (skeletal and cellular). Metabolic actions include ↑ protein synthesis; ↑ carbohydrate metabolism; Lipid mobilization; Retention of sodium, phosphorus, and potassium. Somatropin has the same amino acid sequence as naturally occurring growth hormone and is produced by recombinant DNA techniques. Growth hormone enhances GI tract mucosal transport of water, electrolytes, and nutrients. Therapeutic Effects: Enhanced GI absorption of water, electrolytes, and nutrients in short bowel syndrome.

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Adverse Reactions/Side Effects
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CV: edema of the hands and feet. CNS: fever, malaise, dizziness. Derm: swelling of hands and feet. Endo: hyperglycemia, hypothyroidism, insulin resistance. GI: flatulence, vomiting. Local: pain at injection site, local lipoatrophy, or lipodystrophy with SC use. MS: arthralgia, musculoskeletal pain.

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PHYSICAL THERAPY IMPLICATIONS

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Examination and Evaluation
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  • Monitor body weight and other symptoms (weakness, fatigue, malaise) to help document whether this drug is successful in enhancing GI absorption of nutrients, water, and electrolytes.

  • Assess edema in the hands and feet using girth measurements, volume displacement, and measurement of pitting edema (See Appendix N). Report increased swelling, especially if ROM and function are compromised.

  • Assess any joint pain or muscle pain to rule out musculoskeletal pathology; that is, try to determine if pain is drug induced rather than caused by anatomic or biomechanical problems.

  • Be alert for signs of hyperglycemia and insulin resistance, including confusion, drowsiness, flushed/dry skin, fruit-like breath odor, rapid/deep breathing, polyuria, loss of appetite, and unusual thirst. Patients with diabetes mellitus should check blood glucose levels frequently.

  • Monitor any decrease in metabolism that might indicate hypothyroidism. Common signs include bradycardia, lethargy, cold intolerance, weight gain, and muscle weakness. Report these signs to the physician.

  • Assess dizziness that might affect gait, balance, and other functional activities (See Appendix C). Report balance problems and functional limitations to the physician, and caution the patient and family/caregivers to guard against falls and trauma.

  • Monitor subcutaneous injection site for bruising or decreased local fat accumulation (lipoatrophy, lipodystrophy). Report prolonged or excessive injection site reactions to the physician.

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Interventions
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  • Do not apply physical agents (heat, cold, electrotherapeutic modalities) or massage over the injection site; these interventions can alter drug absorption from subcutaneous tissues.

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Patient/Client-Related Instruction
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  • Advise patient and family/caregivers to adhere to recommended dosing schedule. Emphasize that growth hormones must not be used to increase athletic performance, and that administration to people without growth hormone deficiency or after epiphyseal closure may result in acromegaly (coarsening of facial features; enlarged hands, feet, and internal organs; increased blood glucose; hypertension).

  • Instruct patient and family/caregivers to report other troublesome side effects such as severe or ...

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