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INTRODUCTION

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sertaconazole (ser-ta-kon-a-zole)

Ertaczo

Classification

Therapeutic: antifungals

Pharmacologic: imidazoles

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Indications
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Topical treatment of interdigital tinea pedis in immunocompetent patients >12 yr.

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Action
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Inhibits synthesis of ergosterol, a component of fungal cell membrane, resulting in cytoplasmic leakage and fungal cell death. Therapeutic Effects: Resolution of fungal infection. Spectrum: Active against Trichophyton rubrum, T. mentagrophytes, Epidermophyton floccosum.

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Adverse Reactions/Side Effects
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Derm: application site reactions, burning, contact dermatitis, dry skin, tenderness.

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PHYSICAL THERAPY IMPLICATIONS

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Examination and Evaluation
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  • Assess healing of skin lesions to help document drug effectiveness.

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Interventions
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  • Avoid contact with cutaneous lesions when treating patient.

  • Always wash hands thoroughly and disinfect equipment (whirlpools, electrotherapeutic devices, treatment tables, and so forth) to help prevent the spread of infection.

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Patient/Client-Related Instruction
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  • Advise patient to report any increased local sensitivity to this drug (pain, burning, itching, swelling).

  • Instruct patient about proper hygiene; e.g., thoroughly wash and dry the affected area, wear clean socks and ventilated shoes for tinea pedis, and so forth.

  • Advise patient to apply the drug as directed for the full course of treatment even if feeling better.

  • Inform patient that full therapeutic response may take up to 4 wk.

  • Advise patient to seek medical help if infections persist or recur after the full treatment. Recurrent fungal infections may be a sign of systemic illness.

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Pharmacokinetics
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Absorption: Minimal systemic absorption.

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Distribution: Unknown.

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Metabolism and Excretion: Unknown.

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Half-life: Unknown.

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TIME/ACTION PROFILE

ROUTE ONSET PEAK DURATION
topical within 2 wk unknown unknown

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Contraindications/Precautions
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Contraindicated in: Hypersensitivity to sertaconazole or other imidazoles.

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Use Cautiously in: Children <12 yr, lactation (safety not established); Pregnancy (use only if clearly needed).

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Interactions
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Drug-Drug: None noted.

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Route/Dosage
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Topical (Adults and Children >12 yr): Apply bid for 4 wk.

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Availability
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2% cream: 15-g tube, 30-g tube.

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