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INTRODUCTION

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phenazopyridine (fen-az-oh-peer-i-deen)

Azo-Standard, Baridium, Geridium,

Image not available.Phenazo, Prodium, Pyridiate, Pyridium, Pyridium Plus, Urodine, Urogesic, UTI Relief

Classification

Therapeutic: nonopioid analgesics

Pharmacologic: urinary tract analgesics

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Indications
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Provides relief from the following urinary tract symptoms, which may occur in association with infection or following urologic procedures: Pain, Itching, Burning, Urgency, Frequency.

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Action
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Acts locally on the urinary tract mucosa to produce analgesic or local anesthetic effects. Has no antimicrobial activity. Therapeutic Effects: Diminished urinary tract discomfort.

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Adverse Reactions/Side Effects
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CNS: headache, vertigo. GI: hepatotoxicity, nausea. GU: bright-orange urine, renal failure. Derm: rash. Hemat: hemolytic anemia, methemoglobinemia.

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PHYSICAL THERAPY IMPLICATIONS

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Examination and Evaluation
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  • Be alert for signs of liver toxicity, including anorexia, abdominal pain, severe nausea and vomiting, yellow skin or eyes, skin rashes, flu-like symptoms, and muscle/joint pain. Report these signs to the physician immediately.

  • Monitor signs of hemolytic anemia (unusual fatigue, shortness of breath, dizziness, headache, pale skin, chest pain, coldness in hands and feet) and methemoglobinemia (bluish coloring of the skin, lips fingernails; headache; shortness of breath; lack of energy). Notify physician immediately if these signs occur.

  • Monitor signs of renal failure, including decreased urine output, increased blood pressure, muscle cramps/twitching, edema/weight gain from fluid retention, yellowish brown skin, and confusion that progresses to seizures and coma. Report these signs to the physician immediately.

  • Assess pain and other urinary tract symptoms (burning, itching, urinary frequency) to document whether this drug is successful in helping manage the patient's pain.

  • Assess vertigo that might affect gait, balance, and other functional activities. Report balance problems and functional limitations to the physician and nursing staff, and caution the patient and family/caregivers to guard against falls and trauma.

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Patient/Client-Related Instruction
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  • Instruct patient and family/caregivers to report other troublesome side effects such as severe or prolonged headache, nausea, or skin rash.

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Pharmacokinetics
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Absorption: Appears to be well absorbed following oral administration.

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Distribution: Unknown. Small amounts cross the placenta.

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Metabolism and Excretion: Rapidly excreted unchanged in the urine.

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Half-life: Unknown.

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TIME/ACTION PROFILE (urinary analgesia)

ROUTE ONSET PEAK DURATION
PO unknown 5–6 hr 6–8 hr

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Contraindications/Precautions
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Contraindicated in: Hypersensitivity; Glomerulonephritis; Severe hepatitis, uremia, or renal failure; Renal insufficiency; G6PD deficiency.

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Use Cautiously in: Hepatitis; Pregnancy or lactation (safety not established).

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Interactions
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Drug-Drug: None significant.

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Route/Dosage
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PO (Adults): 200 mg tid for 2 days.

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PO (Children): 4 mg/kg tid for 2 days.

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Availability (generic available)
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Tablets:...

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