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INTRODUCTION

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oxiconazole (ox-i-kon-a-zole)

Oxistat

Classification

Therapeutic: antifungals (topical)

Pharmacologic: imidazoles

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Indications
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Treatment of a variety of cutaneous fungal infections, including tinea pedis (athlete's foot), tinea cruris (jock itch), tinea corporis (ringworm), and tinea versicolor (cream only).

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Action
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Affects the synthesis of the fungal cell wall. Therapeutic Effects: Decrease in symptoms of fungal infection.

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Adverse Reactions/Side Effects
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Local: burning, itching, local hypersensitivity reactions, redness, stinging.

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PHYSICAL THERAPY IMPLICATIONS

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Examination and Evaluation
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  • Assess healing of skin lesions to help document drug effectiveness.

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Interventions
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  • Avoid contact with cutaneous lesions when treating patient.

  • Always wash hands thoroughly and disinfect equipment (whirlpools, electrotherapeutic devices, treatment tables, and so forth) to help prevent the spread of infection.

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Patient/Client-Related Instruction
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  • Advise patient to report any increased local sensitivity to this drug (pain, burning, itching, swelling).

  • Instruct patient about proper hygiene; e.g., thoroughly wash and dry the affected area, wear clean socks and ventilated shoes for tinea pedis, and so forth.

  • Advise patient to apply the drug as directed for the full course of treatment even if feeling better.

  • Inform patient that early relief of cutaneous symptoms may be seen in 2–3 days. Full therapeutic response may take 2 wk for tinea cruris, tinea corporis, and tinea versicolor and 4 wk for tinea pedis.

  • Advise patient to seek medical help if infections persist or recur after the full treatment. Recurrent fungal infections may be a sign of systemic illness.

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Pharmacokinetics
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Absorption: Absorption through intact skin is minimal.

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Distribution: Distribution after topical administration is primarily local.

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Metabolism and Excretion: Systemic metabolism and excretion not known following local application.

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Half-life: Not applicable.

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TIME/ACTION PROFILE

ROUTE ONSET PEAK DURATION
topical unknown unknown unknown

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Contraindications/Precautions
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Contraindicated in: Hypersensitivity to active ingredients, additives, preservatives, or bases.

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Use Cautiously in: Nail and scalp infections (may require additional systemic therapy); OB/Lactation: Safety not established.

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Interactions
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Drug-Drug: Not known.

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Route/Dosage
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Topical (Adults and Children): Apply cream or lotion once or twice daily in patients with tinea pedis, tinea corporis, or tinea cruris. Apply cream once daily in patients with tinea versicolor. Patients with tinea corporis, tinea cruris, or tinea versicolor should be treated for 2 wk. Patients with tinea pedis should be treated for 4 wk.

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Availability
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Cream: 1%. Lotion: 1%.

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