Absence seizures (petit mal).
Elevates the seizure threshold. Suppresses abnormal wave and spike activity associated with absence (petit mal) seizures. Therapeutic Effects: Prevention of absence (petit mal) seizures.
Adverse Reactions/Side Effects
CNS: INCREASED FREQUENCY OF TONIC-CLONIC (GRAND MAL) SEIZURES, dizziness, drowsiness, euphoria, fatigue, headache, hyperactivity, irritability, psychiatric disturbances. EENT: myopia. GI: abdominal pain, anorexia, cramping, diarrhea, nausea, vomiting, weight loss, hiccups. GU: pink/brown discoloration of urine, vaginal bleeding. Derm: STEVENS-JOHNSON SYNDROME, hirsutism, rashes, urticaria. Hemat: agranulocytosis, eosinophilia, leukopenia, pancytopenia. Neuro: ataxia. Misc: systemic lupus erythematosus.
PHYSICAL THERAPY IMPLICATIONS
Examination and Evaluation
Document the number, duration, and severity of seizures to help determine if this drug is effective in reducing seizure activity. Be especially alert for tonic-clonic seizure activity, and report an increase in the frequency of these seizures to the physician immediately.
Monitor skin reactions such as rash, itching/burning skin, hives, exfoliation, and dermatitis. Notify physician immediately about because certain skin reactions may indicate serious hypersensitivity reactions (Stevens-Johnson syndrome).
Be alert for signs of agranulocytosis and leukopenia (fever, sore throat, mucosal lesions, signs of infection), eosinophilia (fatigue, weakness, myalgia), or fatigue and poor health that might be due to other blood dyscrasias. Report these signs to the physician immediately. Periodic blood tests may be needed to monitor WBC and RBC counts.
Assess dizziness or ataxia that might affect gait, balance, and other functional activities (See Appendix C). Report balance problems and functional limitations to the physician, and caution the patient and family/caregivers to guard against falls and trauma.
Monitor daytime drowsiness, euphoria, irritability, or other psychiatric disturbances. Repeated or excessive symptoms may require change in dose or medication.
Monitor signs of drug-induced lupus syndrome, including increased blood pressure (BP), fever, joint pain, skin rashes, and redness/irritation of the eye (uveitis). Notify physician promptly if these signs appear.
Periodically assess body weight and other anthropometric measures (body mass index, body composition). Report a rapid or unexplained weight loss or decreased body fat.
Guard against falls and trauma (hip fractures, head injury, and so forth), especially if dizziness or ataxia affects gait and balance. Implement fall prevention strategies, especially if balance is impaired (See Appendix E).
Advise patient to avoid alcohol and other CNS depressants because of the increased risk of sedation and adverse effects.
Advise patients on prolonged antiseizure therapy not to discontinue medication without consulting their physician. Abrupt withdrawal may cause increased seizures.
Advise patient about the risk of daytime drowsiness and decreased attention and mental focus. Use care if driving or in other activities that require strong concentration and fast responses.
Advise patient about the ...
Log In to View More
If your institution is currently a subscriber
of the F.A. Davis PT Collection please sign in below.
If your institution is not a subscriber
please click here
to learn more.
Want remote access to your institution's subscription?
Sign in to your MyAccess profile while you are actively authenticated on this site via your institution (you will be able to verify this by looking at the top right corner of the screen - if you see your institution's name, you are authenticated). Once logged in to your MyAccess profile, you will be able to access your institution's subscription for 90 days from any location. You must be logged in while authenticated at least once every 90 days to maintain this remote access.
If your institution subscribes to this resource, and you don't have a MyAccess profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus.
Pop-up div Successfully Displayed
This div only appears when the trigger link is hovered over.
Otherwise it is hidden from view.