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INTRODUCTION

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dutasteride (doo-tas-te-ride)

Avodart

Classification

Therapeutic: benign prostatic hyperplasia (BPH) agents

Pharmacologic: androgen inhibitors

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Indications
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Management of the symptoms of BPH in men with an enlarged prostate gland (alone or with tamsulosin).

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Action
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Inhibits the enzyme 5-alpha-reductase, which is responsible for converting testosterone to its potent metabolite 5-alpha-dihydrotestosterone in the prostate gland and other tissues. 5-Alpha-dihydrotestosterone is partly responsible for prostatic hyperplasia. Therapeutic Effects: Reduced prostate size with associated decrease in urinary symptoms.

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Adverse Reactions/Side Effects
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GU: decreased libido, ejaculation disorders, erectile dysfunction. Endo: gynecomastia. Derm: rash, urticaria. Misc: ALLERGIC REACTIONS, ANGIOEDEMA.

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PHYSICAL THERAPY IMPLICATIONS

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Examination and Evaluation
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  • Monitor signs of allergic reactions and angioedema, including pulmonary symptoms (tightness in the throat and chest, wheezing, cough, dyspnea), skin reactions (rash, pruritus, urticaria, swelling in the face). Notify physician immediately of these signs.

  • Monitor signs of BPH such as difficulty starting a urine stream, painful urination, weak urine flow, feeling that the bladder is not completely empty, frequent nighttime urination, and an urge to urinate again soon after urinating. Document any change in BPH symptoms to help assess the effects of drug therapy.

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Patient/Client-Related Instruction
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  • When treating BPH, advise patient that urinary symptoms (retention, dribbling, hesitancy, urgency) should improve, and to contact the physician if these symptoms continue to worsen.

  • Instruct patient or family/caregivers to report other bothersome side effects such as breast enlargement (gynecomastia), severe or prolonged skin reactions (rash, hives), or sexual dysfunction (decreased libido, ejaculation disorders, erectile dysfunction).

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Pharmacokinetics
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Absorption: Well absorbed (60%) following oral administration; also absorbed through skin.

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Distribution: 11.5% of serum concentration partitions into semen.

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Protein Binding: 99% bound to albumin; 96.6% bound to alpha-1 glycoprotein.

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Metabolism and Excretion: Mostly metabolized by the liver via the CYP3A4 metabolic pathway; metabolites are excreted in feces.

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Half-life: 5 wk.

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TIME/ACTION PROFILE (reduction in dihydrotestosterone levels†)

ROUTE ONSET PEAK DURATION
PO unknown* 1–2 wk unknown

*Symptoms may only improve over 3–12 mo.

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Contraindications/Precautions
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Contraindicated in: Hypersensitivity; Cross-sensitivity with other 5-alpha-reductase inhibitors may occur; Women; Pedi: Children.

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Use Cautiously in: Hepatic impairment.

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Interactions
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Drug-Drug: Blood levels and effects may be increased by ritonavir, ketoconazole, verapamil, diltiazem, cimetidine, ciprofloxacin, or other CYP3A4 enzyme inhibitors.

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Route/Dosage
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PO (Adults): 0.5 mg once daily (with or without tamsulosin).

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Availability
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Soft gelatin capsules: 0.5 mg.

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Image not available. = Canadian drug name; *CAPITALS ...

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