Skip to Main Content

++

INTRODUCTION

++

difluprednate (ophthalmic) (dye-floo-pred-nate)

Durezol

Classification

Therapeutic: ocular agents

Pharmacologic: corticosteroids

++
Indications
++

Treatment of inflammation and pain associated with ocular surgery.

++
Action
++

Decreases inflammation. Therapeutic Effects: Decreased pain and inflammation following ocular surgery.

++
Adverse Reactions/Side Effects
++

(CAPITALS indicate life-threatening; underlines indicate most frequent.) EENT: ↑ intraocular pressure, blepharitis, cataracts, conjunctival hyperemia, corneal edema, delayed healing, eye pain, infections, iritis, photophobia.

++

PHYSICAL THERAPY IMPLICATIONS

++
Examination and Evaluation
++

  • Assess the eye to help document whether drug therapy is successful in resolving ocular pain and inflammation.

  • Monitor any new or increased reactions at the site of application such as pain, infection, swelling, redness, cloudy/blurry vision, and increased sensitivity to light (photophobia). Report increased ocular reactions to the physician.

++
Patient/Client-related Instruction
++

  • Check that the patient and family or caregivers understand proper use of eye drops, and adhere to the recommended dosing schedule.

++
Pharmacokinetics
++

Absorption: Limited systemic absorption.

++

Distribution: Unknown.

++

Metabolism and Excretion: Unknown.

++

Half-life: Unknown.

++

Table Graphic Jump Location
Favorite Table | Download (.pdf) | Print

TIME/ACTION PROFILE

ROUTE ONSET PEAK DURATION
Ophth unknown unknown unknown

++
Contraindications/Precautions
++

Contraindicated in: Active viral, mycobacterial or fungal infection of eyes and surrounding structures.

++

Use Cautiously in: OB: Use in pregnancy only if potential benefit justifies potential risk to the fetus; Lactation: Use cautiously during lactation; Pedi: Safety and effectiveness in children have not been established.

++
Interactions
++

Drug-Drug: None noted.

++
Route/Dosage
++

Ophth (Adults): 1 drop four times daily, starting 24 hr after surgery for 2 wk, then twice daily for 1 week, then further tapered based on response.

++
Availability
++

Ophthalmic emulsion: 0.05% in 5 mL bottle.

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.