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INTRODUCTION

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difluprednate (ophthalmic) (dye-floo-pred-nate)

Durezol

Classification

Therapeutic: ocular agents

Pharmacologic: corticosteroids

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Indications
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Treatment of inflammation and pain associated with ocular surgery.

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Action
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Decreases inflammation. Therapeutic Effects: Decreased pain and inflammation following ocular surgery.

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Adverse Reactions/Side Effects
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(CAPITALS indicate life-threatening; underlines indicate most frequent.) EENT: ↑ intraocular pressure, blepharitis, cataracts, conjunctival hyperemia, corneal edema, delayed healing, eye pain, infections, iritis, photophobia.

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PHYSICAL THERAPY IMPLICATIONS

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Examination and Evaluation
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  • Assess the eye to help document whether drug therapy is successful in resolving ocular pain and inflammation.

  • Monitor any new or increased reactions at the site of application such as pain, infection, swelling, redness, cloudy/blurry vision, and increased sensitivity to light (photophobia). Report increased ocular reactions to the physician.

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Patient/Client-related Instruction
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  • Check that the patient and family or caregivers understand proper use of eye drops, and adhere to the recommended dosing schedule.

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Pharmacokinetics
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Absorption: Limited systemic absorption.

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Distribution: Unknown.

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Metabolism and Excretion: Unknown.

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Half-life: Unknown.

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TIME/ACTION PROFILE

ROUTE ONSET PEAK DURATION
Ophth unknown unknown unknown

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Contraindications/Precautions
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Contraindicated in: Active viral, mycobacterial or fungal infection of eyes and surrounding structures.

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Use Cautiously in: OB: Use in pregnancy only if potential benefit justifies potential risk to the fetus; Lactation: Use cautiously during lactation; Pedi: Safety and effectiveness in children have not been established.

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Interactions
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Drug-Drug: None noted.

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Route/Dosage
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Ophth (Adults): 1 drop four times daily, starting 24 hr after surgery for 2 wk, then twice daily for 1 week, then further tapered based on response.

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Availability
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Ophthalmic emulsion: 0.05% in 5 mL bottle.

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