Skip to Main Content

++

INTRODUCTION

++

clobetasol (kloe-bay-ta-sol)

Clobex, Image not available.Dermovate, Temovate, Temovate E

Classification

Therapeutic: anti-inflammatories (steroidal)

Pharmacologic: corticosteroids

++
Interventions
++

  • Protect skin from breakdown, especially over bony prominences.

++
Patient/client-Related Instruction
++

  • Advise patients on long-term treatment to consult physician before stopping this medication. Stopping the medication suddenly may result in adrenocortical shock (severe hypotension, hypoglycemia, weakness, vomiting). If these signs appear, notify physician immediately; may be life threatening.

  • Check that the patient and family or caregivers understand topical application procedures and adhere to the recommended dosing schedule.

++
Pharmacokinetics
++

Absorption: Minimal. Prolonged use on large surface areas or large amounts applied or use of occlusive dressings may increase systemic absorption.

++

Distribution: Remains primarily at site of action.

++

Metabolism and Excretion: Usually metabolized in skin; may be modified to resist local metabolism and have a prolonged local effect.

++

Half-life: Unknown.

++

Table Graphic Jump Location
Favorite Table | Download (.pdf) | Print

TIME/ACTION PROFILE (response depends on condition being treated)

ROUTE ONSET PEAK DURATION
topical mins–hrs hrs–days hrs–days

++
Contraindications/Precautions
++

Contraindicated in: Hypersensitivity or known intolerance to corticosteroid or components of vehicles (ointment or cream base, preservative, alcohol); Untreated bacterial or viral infections.

++

Use Cautiously in: Hepatic dysfunction; Diabetes mellitus, cataracts, glaucoma, or tuberculosis (use of large amounts of high-potency agents may worsen condition); Patients with preexisting skin atrophy; OB/Lactation/Pedi: Pregnancy, lactation, or children (chronic high-dose use may result in adrenal suppression in mother, growth suppression in children; children may be more susceptible to adrenal and growth suppression); Not recommended for use in children <12 yr.

++
Interactions
++

Drug-Drug: None significant.

++
Route/Dosage
++

Topical (Adults and Children): Apply to affected area(s) 1–3 times daily (depends on preparation and condition being treated).

++
Availability (generic available)
++

Cream: 0.05%. Emollient cream: 0.05%. Foam: 005%. Gel: 0.05%. Lotion: 0.05%. Ointment: 0.05%. Scalp solution: 0.05%. Shampoo: 0.05%. Spray: 0.05%.

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.