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INTRODUCTION

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clobetasol (kloe-bay-ta-sol)

Clobex, Image not available.Dermovate, Temovate, Temovate E

Classification

Therapeutic: anti-inflammatories (steroidal)

Pharmacologic: corticosteroids

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Interventions
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  • Protect skin from breakdown, especially over bony prominences.

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Patient/client-Related Instruction
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  • Advise patients on long-term treatment to consult physician before stopping this medication. Stopping the medication suddenly may result in adrenocortical shock (severe hypotension, hypoglycemia, weakness, vomiting). If these signs appear, notify physician immediately; may be life threatening.

  • Check that the patient and family or caregivers understand topical application procedures and adhere to the recommended dosing schedule.

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Pharmacokinetics
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Absorption: Minimal. Prolonged use on large surface areas or large amounts applied or use of occlusive dressings may increase systemic absorption.

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Distribution: Remains primarily at site of action.

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Metabolism and Excretion: Usually metabolized in skin; may be modified to resist local metabolism and have a prolonged local effect.

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Half-life: Unknown.

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TIME/ACTION PROFILE (response depends on condition being treated)

ROUTE ONSET PEAK DURATION
topical mins–hrs hrs–days hrs–days

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Contraindications/Precautions
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Contraindicated in: Hypersensitivity or known intolerance to corticosteroid or components of vehicles (ointment or cream base, preservative, alcohol); Untreated bacterial or viral infections.

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Use Cautiously in: Hepatic dysfunction; Diabetes mellitus, cataracts, glaucoma, or tuberculosis (use of large amounts of high-potency agents may worsen condition); Patients with preexisting skin atrophy; OB/Lactation/Pedi: Pregnancy, lactation, or children (chronic high-dose use may result in adrenal suppression in mother, growth suppression in children; children may be more susceptible to adrenal and growth suppression); Not recommended for use in children <12 yr.

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Interactions
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Drug-Drug: None significant.

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Route/Dosage
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Topical (Adults and Children): Apply to affected area(s) 1–3 times daily (depends on preparation and condition being treated).

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Availability (generic available)
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Cream: 0.05%. Emollient cream: 0.05%. Foam: 005%. Gel: 0.05%. Lotion: 0.05%. Ointment: 0.05%. Scalp solution: 0.05%. Shampoo: 0.05%. Spray: 0.05%.

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