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INTRODUCTION

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bepotastine (be-poe-tass-teen)

Bepreve

Classification

Therapeutic: ocular agents

Pharmacologic: antihistamines

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Indications
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Treatment of itching associated with allergic conjunctivitis.

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Action
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Acts as a histamine H1 receptor antagonist; also inhibits the release of histamine from mast cells; does not bind to or inactivate histamine. Therapeutic Effects: Decreased ocular itching associated with allergic conjunctivitis.

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Adverse Reactions/Side Effects
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CNS: headache. EENT: nasopharyngitis. GI: taste in mouth following instillation.

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PHYSICAL THERAPY IMPLICATIONS

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Examination and Evaluation
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  • Monitor eye pain, itching, and inflammation to help document whether drug therapy is successful in resolving allergic conjunctivitis.

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Patient/Client-Related Instruction
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  • Check that the patient and family or caregivers understand ophthalmic application procedures and adhere to the recommended dosing schedule.

  • Instruct patient and family/caregivers to report other troublesome side effects such as severe or prolonged headache, altered taste, or inflammation of the nose and pharynx.

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Pharmacokinetics
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Absorption: Some systemic absorption follows ophthalmic administration.

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Distribution: Unknown

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Metabolism and Excretion: Minimally metabolized by the liver; 75–90% excreted unchanged in urine

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Half-life: Unknown

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TIME/ACTION PROFILE (antihistaminic activity)

ROUTE ONSET PEAK DURATION
ophthalmic within 15 min 1–2 hr* 12 hr

*Blood levels.

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Contraindications/Precautions
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Contraindicated in: Hypersensitivity.

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Use Cautiously in: Contact lens use OB: Use during pregnancy if potential maternal benefit justifies the potential risk to fetus; Lactation: Use cautiously during breastfeeding; Pedi: Safe and effective use in children <2 yr has not been established.

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Interactions
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Drug-Drug: None noted

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Route/Dosage
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Ophthalmic (Adults): 1 drop in affected eye(s) twice daily.

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Availability
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Ophthalmic solution: 1.5%

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