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INTRODUCTION

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benazepril (ben-aye-ze-pril)

Lotensin

Classification

Therapeutic: antihypertensives

Pharmacologic: ACE inhibitors

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Indications
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Alone or with other agents in the management of hypertension.

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Action
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Angiotensin-converting enzyme (ACE) inhibitors block the conversion of angiotensin I to the vasoconstrictor angiotensin II. ACE inhibitors also prevent the degradation of bradykinin and other vasodilatory prostaglandins. ACE inhibitors also increase plasma renin levels and reduce aldosterone levels. Net result is systemic vasodilation. Therapeutic Effects: Lowering of blood pressure in patients with hypertension.

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Adverse Reactions/Side Effects
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CNS: dizziness, drowsiness, fatigue, headache. Resp: cough. CV: hypotension. GI: nausea. GU: impaired renal function. Derm: rashes. F and E: hyperkalemia. Misc: ANGIOEDEMA.

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PHYSICAL THERAPY IMPLICATIONS

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Examination and Evaluation
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  • Monitor signs of angioedema, including rashes, raised patches of red or white skin (welts), burning/itching skin, swelling in the face, and difficulty breathing. Notify physician of these signs immediately.

  • Assess blood pressure periodically and compare to normal values (See Appendix F) to help determine antihypertensive effects. Report low blood pressure (hypotension), especially if patient experiences dizziness, fatigue, or other symptoms.

  • Assess dizziness and drowsiness that might affect gait, balance, and other functional activities (See Appendix C). Report balance problems and functional limitations to the physician, and caution the patient and family/caregivers to guard against falls and trauma.

  • Be alert for signs of high plasma potassium levels (hyperkalemia), including bradycardia, fatigue, weakness, numbness, and tingling. Notify physician because severe cases can lead to life-threatening arrhythmias and paralysis.

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Interventions
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  • Avoid physical therapy interventions that cause systemic vasodilation (large whirlpool, Hubbard tank). Additive effects of this drug and the intervention may cause a dangerous fall in blood pressure.

  • To minimize orthostatic hypotension, patient should move slowly when assuming a more upright position.

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Patient/Client-Related Instruction
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  • Remind patients to take medication as directed to control hypertension and other cardiac conditions even if they are asymptomatic.

  • Counsel patients about additional interventions to help control blood pressure, including regular exercise, weight loss, sodium restriction, stress reduction, moderation of alcohol consumption, and smoking cessation.

  • Instruct patient to report signs of impaired renal function, including decreased urine output, cloudy urine, or sudden weight gain due to fluid retention.

  • Instruct patient to notify physician of a prolonged dry cough; drug therapy may need to be altered to resolve this side effect.

  • Instruct patient or family/caregivers to report other troublesome side effects such as severe or prolonged headache, nausea, or skin rash.

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Pharmacokinetics
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Absorption: 37% absorbed after oral administration.

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Distribution: Crosses the placenta; enters breast milk in small amounts.

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Protein Binding: 95%.

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Metabolism and Excretion: Converted by the liver to benazeprilat, the active metabolite; 20% excreted in ...

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