Airet, Apo-Salvent, Gen-Salbutamol, Novo-Salmol, Proventil, Proventil HFA, Ventodisk, Ventolin, Ventolin HFA, Ventolin nebules, Ventolin rotacaps
Used as a bronchodilator to control and prevent reversible airway obstruction caused by asthma or COPD. Inhaln: Used as a quick-relief agent for acute bronchospasm and for prevention of exercise-induced bronchospasm. PO: Used as a long-term control agent in patients with chronic/persistent bronchospasm.
Binds to beta2-adrenergic receptors in airway smooth muscle, leading to activation of adenyl cyclase and increased levels of cyclic-3,′,5,′ adenosine monophosphate (cAMP). Increases in cAMP activate kinases, which inhibit the phosphorylation of myosin and decrease intracellular calcium. Decreased intracellular calcium relaxes smooth muscle airways. Relaxation of airway smooth muscle with subsequent bronchodilation. Relatively selective for beta2 (pulmonary) receptors. Therapeutic Effects: Bronchodilation.
Adverse Reactions/Side Effects
CNS: nervousness, restlessness, tremor, headache, insomnia (Pedi: occurs more frequently in young children than adults), hyperactivity in children. CV: chest pain, palpitations, angina, arrhythmias, hypertension. GI: nausea, vomiting. Endo: hyperglycemia. F and E: hypokalemia.
PHYSICAL THERAPY IMPLICATIONS
Examination and Evaluation
Assess pulmonary function at rest and during exercise (see Appendixes I, J, K) to document effectiveness of medication in controlling bronchospasm.
Monitor signs of paradoxical bronchospasm (wheezing, cough, dyspnea, tightness in chest and throat), especially at higher or excessive doses. If condition occurs, advise patient to withhold medication and notify physician immediately.
Assess blood pressure periodically and compare to normal values (see Appendix F). Report a sustained increase in blood pressure (hypertension) to the physician.
Assess heart rate, ECG, and heart sounds, especially during exercise (see Appendixes G, H). Report any rhythm disturbances or symptoms of increased arrhythmias, including palpitations, chest discomfort, shortness of breath, fainting, and fatigue/weakness.
Monitor and report signs of CNS toxicity, including nervousness, restlessness, tremor, or hyperactivity. Sustained or severe CNS signs may indicate overdose or excessive use of this drug.
Monitor signs of hyperglycemia, including drowsiness, fruity breath, increased urination, and unusual thirst. Patients with diabetes mellitus should check blood glucose levels frequently.
Monitor and report any muscle weakness, aches, or cramps that might indicate low potassium levels (hypokalemia).
When implementing airway clearance techniques or respiratory muscle training, attempt to intervene when the airway is maximally bronchodilated. Peak responses typically occur 60–90 min after inhalation or 2–3 hr after oral administration.
Use caution during aerobic exercise and endurance conditioning because of the risk of cardiovascular stimulation. Cardiac effects should be minimal at lower oral doses or occasional inhaled use. Cardiovascular effects such as arrhythmias, angina pectoris, or increased blood pressure may occur at higher doses or during excessive use, and are caused by inadvertent stimulation of ...
Log In to View More
If your institution is currently a subscriber
of the F.A. Davis PT Collection please sign in below.
If your institution is not a subscriber
please click here
to learn more.
Want remote access to your institution's subscription?
Sign in to your MyAccess profile while you are actively authenticated on this site via your institution (you will be able to verify this by looking at the top right corner of the screen - if you see your institution's name, you are authenticated). Once logged in to your MyAccess profile, you will be able to access your institution's subscription for 90 days from any location. You must be logged in while authenticated at least once every 90 days to maintain this remote access.
If your institution subscribes to this resource, and you don't have a MyAccess profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus.
Pop-up div Successfully Displayed
This div only appears when the trigger link is hovered over.
Otherwise it is hidden from view.